PDF | The present study aims to evaluate the therapeutic properties of the medicinal plants (Vitex negundo, Aegle marmelos and Boswellia serrata) for their . Abstract To evaluate the anti-inflammatory activity of Vitex negundo (VN) leaf extract and its mechanism of action in experimental animals. Carrageenin induced. Abstract. The present study was undertaken to assess the anti-inflammatory effect of ethanolic extract of Vitex negundo roots in rats.

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Antioxidant and Antiinflammatory Activity of Vitex negundo.

This article has been cited by other articles in PMC. I method of assay and effects of storage. Support Center Support Center. The prostaglandins are known to play important role in genesis of sign and symptoms of acute inflammation Mocada et al. Hence, reduction of anfi stress produced by VN might possibly be due to these chemical constituents.

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How to cite this article: Footnotes Kulkarni, et al.: Wiley Series Chemistry and Pharmacology of Drugs. Antiinflammatory activity, antioxidant activity, total polyphenol content, Vitex negundo. The paw edema volume was measured with the help of plethysmometer at zero hour. Five groups of 6 mice each were administered with aqueous extract at 1.

The anti-inflammatory activity in this dose of the test drug was comparable to phenylbutazone mg kg -1 PO. Shri Satguru Publication 3: Similarly, fresh leaves of VN have been suggested to possess neundo and pain suppressing activities possibly mediated via PG synthesis inhibition, antihistamine, membrane stabilising and antioxidant activities Negundp et al.

Group I served as toxicant control, received carrageenan 0. Inhibitory effect of Vitex-negundo extract on oxytocin induced contractions in rat uterus in a dose dependant manner. We also extend our sincere thanks to Dr. The results strongly suggest that radical quenching may be one of the mechanisms responsible for its antiinflammatory activity.

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Antioxidant and Antiinflammatory Activity of Vitex negundo.

The response of uterine tissue to oxytocin 0. Herbal drugs play an important role in health care programs especially in developing countries. Ayurveda mentions several plants acting as antiinflammatory agents in arthritic disorders.

CDepartment of Biochemistry, for allowing us to perform bio-chemical investigation in the department. Indian Journal of Natural Products and Resources 4: The present investigations have demonstrated a strong correlation between anti-inflammatory and antioxidant activities of V. Leaves are applied externally to bruises and eruption [ 9 ]. The experiment was repeated for ten times. These findings were in agreement with the findings of Telang et al.

Inflqmmatory pastes of leaves are applied externally to megundo the bites of poisonous animals [ 7 ]. The basic literature survey exposed that Vitex negundo hasantioxidant, antiulcer and anti-nociceptive activity and Murraya koenigii possessing anthelmintic, analgesic, cooling activity, but not many scientific studies have been carried out to reveal and collaborate the anti-inflammatory activity of Vitex negundo and Murraya koenigii leaves.

The prevention of oxidative damage to tissue could therefore be one of the mechanisms responsible for the antiinflammatory effect shown by the plant. These observations suggest that VN possesses anti-inflammatory activity against acute as well as sub-acute inflammation, which appear to be due to prostaglandin inhibition and reduction of oxidative stress respectively, which needs to be substantiated by further study.

Curcumin was used as positive control. Vitex negundo VN Linn verbenaceaea large aromatic shrub with typical five foliolate leave pattern, found throughout the greater part of India at warmer zones and ascending to an altitude of m in outer, Western Himalayas.

The pink colour activiy of thiobarbituric acid reacting substances was monitored at nm 8 — The content were mixed well and kept at room temperature for 15 min. National Center for Biotechnology InformationU. The filtrates were kept on water bath to obtain the crude extract [ 10 ]. The clearance for the use of animals for experimental purpose was obtained from institutional ethical committee constituted for the purpose at M.


The phenolics, particularly polyphenols exhibit a wide variety of beneficial activities in mammals including antiviral, antibacterial, immune stimulating, antiallergic, antihypertensive, antiischemic, antiarrythmic, antithrombotic, hypocholesteromic, hepatoprotective, antiinflammatory, anticarcinogenic Plasma was separated by centrifugation at rmp for 10 min.

The total methanol extract of the plant was standardized in terms of total polyphenols. Vitex or is mentioned in Ayurveda as useful in treating arthritic disorders.

After decades of serious obsession with the modern medicinal system, people have started looking at the ancient healing systems like Ayurveda, Siddha and Unnani. Moreover very few reports Dharmasiri et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The maximum anti-inflammatory action was observed in 3 h in all the doses of test drug.

Oxidative damage and pathogenesis. Anti Inflammatory Activity The activity was evaluated by using carrageenan induced paw edema in rats. Can’t read the image? Animals were observed vites clinical signs and mortality, continuously for first 2 h. Mice were fasted overnight before the day of experiment negumdo the liver was promptly excised after sacrificing the mice.

Open in a separate window. Cycloxygenase 1 and 2.