Carcinoma Mucoepidermoide de Glándulas Salivales Intraoral: Factores Clínicos y Patológicos e Inmunoexpresión de c-erbB-2 en 29 Casos. Vanessa Fátima. Abstract. AVILA, Rodolfo Esteban et al. Mucoepidermoid Carcinoma of Salivary Glands: Histological and Inmunohistochemical Prognostic Factors. Publisher: El propósito de este estudio es presentar la casuística del carcinoma mucoepidermoide de glándulas salivales de pacientes diagnosticados en el.
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In the present study, was set out to examine MEC behavior and patient outcomes to provide additional information on potential factors that could significantly affect the prognosis of these tumors.
Carcinoma mucoepidermoide de glándulas salivales en Brasil: relación clinicopatológica
Ann Otol Rhinol Laryngol. Casilla D Temuco – Chile Tel.: Carcinoma of the parotid and submandibular glands a study of survival in patients.
Despite the small sample studied our results demonstrated no association among c-erbB-2 expression and demographic or histological grades of MEC. Mucoepidermoid carcinoma of intraoral salivary glands. A total of 16 cases were analyzed over a period of 18 years; males were Data concerning survival recurrence and metastasis were evaluated. Pattern of parotid gland tumors on Crete, Greece: Disease-free survival rates were In 2 cases of low grade cholesterol clefts, macrophages and foreign-body giant cells were observed.
Although the latter may present myoepitelial derivation, carcinoma ex pleomorphic adenoma mucorpidermoide adquired a particular biological behavior in the longstanding process of malignant transformation. Casilla D Temuco – Chile Tel.: There is no consensus about the best antibody for the evaluation of c-erbB-2 irnmunoexpression Hanna et al.
Histologically, the tumors were classified as low, intermediate and high grade, according to Auclair et al. Unlike other studies that used this same grading system, 4,13 the results demonstrate a balance in distribution among the three tumor mucoepidfrmoide subtypes. Histopathologic grading of salivary gland neoplasms.
MECs were staged according to the TNM classification of malignant tumors, 12 and minor salivary gland carcinoms were staged according to their site of origin in a similar fashion to squamous cell carcinomas. Salivary glands ; ucoepidermoid carcinoma ; Prognostic factors. Mucoepidermoid Carcinoma of Salivary Glands: Otolaryngol Head Neck Surg.
Previous studies of c-erbB-2 expression in salivary gland carcinomas are sparse, comprise heterogeneous subtypes, and show contradictory results Locati et al. The mucoepidermiode period in this study ranged from 6 to months median 65 monthsand the 5 and year OS rates were both Immunohistochemical study of c-erbB-2 oncoprotein overexpression in human major salivary gland carcinoma: Evaluation and application of grading criteria in cases.
This overexpression may be due to the process envolving histogenesis and salivals differentiation. Services on Demand Journal. R; Milanezi, E; Olson, S. However, its prognostic value should be validated with clinical studies and survival analyses. Most of the studies show that the palate is the most common site of ocurrence Lopes et al.
Surgical resection was performed in all patients. The tumoral histological grade was associated with the ki67 expression, relevant prognosis factors in MEC. Mucoepidermoid carcinoma of the major salivary glands: Mucoepidermoid carcinoma of intraoral salivary glands. There is a wide variation in these malignant neoplasms over different geographic areas and ethnic groups.
Mucoepidermoid carcinoma of the salivary glands clinical review of 42 cases.
Inmunostaining for ki67 were made. Mucoepidermoid carcinoma of minor salivary glands: P; Quattrone, P; Cantu, G. Review of the literature and clinicopathological analysis of 18 patients. Am J Surg Pathol. Evaluation and application of grading criteria in cases. High grade tumors, on the other hand, seem to arise more often in major salivary glands Kokemueller et al. In our series, patients demonstrated an earlier average age of occurrence, with a peak of incidence in the third and fourth mucoepidefmoide of life, whereas previous studies described a prevalence in fifth and sixth decades of life Auclair et glxndulas.
MEC is reported to manifest variable biologic aggressiveness, basically showing correlation with its histological features and is graded by a 3-tiered system Auclair et al, The Kaplan-Meier method was used to plot survival curves with the log rank test for analysis of cumulative survival rates.
MEC is the most mucoepidermoife malignancy of salivary glands and presents a diverse age distribution Auclair et al; Lopes et al.