Eurand’s Diffucaps® technology enables the development of once-daily controlled-release (CR) capsules or patient-friendly orally disintegrating tablet ( ODT). Download scientific diagram | ORBEXA ® Technology 3) DIFFUCAPS ® Technology: Diffucaps is a multiparticulate bead system comprised of multiple layers of. DIFFUCAPS ® technology 4) DIFFUTAB ® Technology: Diffutab technology enables customized release profiles and region-specific delivery. Diffutab.

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These rhythms allow organism to anticipate and prepare for precise and regular environment changes. Degradation via hydroxyl radicals however, is usually dominant and rapid when HA is injected at inflammatory sites. Electroactive controlled release thin films.

Schematic representation of different drug delivery systems where A sigmoidal release after lag time B delayed release after lag time C sustained release after lag diffucapa D extended release without lag time. This technology depends on osmotic pressure to give pre-programmed, controlled drug delivery to the gastrointestinal tract. There are certain conditions for which such a release pattern is not suitable that demand release of a drug after a lag time.

Geoghegan, Edward J, inventors. An approach for chronotherapeutic diseases. Circadian changes are seen in normal lung function, which reaches a low point in the early morning hours.

Polyelectrolyte contains polymers with comparatively high concentration of ionisable groups along the backbone chain. Drug release from intelligent gels responding to antibody concentration In the human body numerous kinds of bioactive compounds are exist. Three-dimensional printing 3DP is a novel solid freeform fabrication technology that has been applied to the fabrication of complex pharmaceutical drug devices, or three-dimensional printing 3DP is a rapid prototyping RP technology.

Release of the drug in response to those systems results from stimuli-induced changes in the gels or in the micelles, which may deswell, swell or erode in response to the respective stimuli. Magnetically triggered reversible controlled drug delivery from microfabricated polymeric multireservoir devices ; In thermo-responsive hydro gel systems, hydro gels undergo reversible volume changes in response to changes in temperature. These pellet-filled capsules provide for extended release of the drug in the gastrointestinal tract.


Chronobiology is the study of biological rhythms and their mechanisms. The circadian disorders generally require chronopharmacotherapy, which can be easily accomplished by pulsatile drug delivery system in a very organized manner. Increase in the blood sugar level after meal. Recent advances in oral pulsatile drug delivery. World Patent ; Platelet agreeability is increased and fibrinolytic activity is decreased in the morning, leading to a state of relative hypercoagulability of the blood.

The pulsatile system is gaining a lot of interest, as the drug is released completely after defined lag time Fig.

When both these systems come in contact with aqueous medium, the coat emulsifies or erodes after the lag time. This proprietary technology has been developed specifically for weak, basic drugs and involves the incorporation of a pharmaceutically acceptable organic acid or a crystallization-inhibiting polymer onto inert cores and coating the drug-layered beads with proprietary functional polymers. Ultrasound induces release Ultrasound is used as an enhancer for the improvement of drug permeation through a biological barrier, such as skin, lungs, intestinal controlled drug delivery e.

Recent technologies in pulsatile drug delivery systems

Tablets with controlled-rate release of active substances. Limitations of the technology as relating to pharmaceuticals have been addressed, and prototype dosage forms have been fabricated. Angew Chem Int Ed Engl.

Some coatings designed to erode gradually with time, result in the release of drug contained within the particle. Increasing the strength of the ultrasound resulted in a proportional increase in the amount of 5-fluorouracil released.

Stimuli-based drug delivery systems release the drug in response to stimuli that are induced by the biological environment. Delayed pulse release hydrogel matrix tablet. US Patent ; 3: Humans exhibit endogenous circadian rhythms that are regulated by the master circadian clock of the body, the suprachiasmatic nucleus. Circadian rhythms Circadian rhythms are technoloyg, endogenous oscillations that occur with a periodicity of about 24 Hours Figure.


Recent technologies in pulsatile drug delivery systems

The characteristic feature of diffkcaps formulation was a well defined lag time followed by a drug pulse with the enclosed active quantity being released at once.

Colon targeted drug delivery: Ritalin methyl phenidate used in the treatment of dkffucaps deficit hyper diffuaps disorder ADHD in children4,8,9,11,13,14,15,16, They reduce the dose frequency, dose size and cost, which ultimately reduces side effects, thereby improving patient compliance. An electric field as an external stimulus has advantages, such as availability of equipment that allows precise control with regard to the magnitude of the current, duration of electric pulses, interval between pulses, etc.

The purpose of designing Multiparticulate dosage form is to develop a reliable formulation that has all the advantages of a single unit formulation. This technology is particularly suitable for drugs that conventionally need multiple daily doses or drugs require customized release formulations. Formulation and in vitro evaluation of floating pulsatile tablets of nizatidine for chronotherpy of ulcers ; 4 5: Amir and Ali J: Floating drug delivery system FDDS and bio adhesive drug delivery are widely used techniques for gastro retention.

The whole unit is coated with an enteric polymer to avoid the problem of variable gastric emptying. This reaction can be used to drive the swelling of a pH-dependent membrane. The body temperature often deviates from the physiological temperature C in the presence of tfchnology or pyrogens. Using this novel technology, SkyePharma has developed Lodotra TMcontaining a diffuaps arthritis drug. PRODAS technology is a combination of both Multiparticulate and hydrophilic matrix tablet technologies in which a number of minitablets gathered in a hard gelatine capsule.