Key words: Intravenous anesthesia, remifentanyl, propofol, infusion pump, .. Aguilera L. Conceptos básicos de farmacocinética farmacodinámia en TIVA. Propofol nanoemulsion is a new formulation consisting of nanoemulsified systems, characterized by the absence of lipid vehicle. Changes in drug vehicle may. Anestesia-Reanimación – A – Propofol – EM|consulte.

Author: Dair Nikolmaran
Country: Lesotho
Language: English (Spanish)
Genre: Art
Published (Last): 21 December 2005
Pages: 454
PDF File Size: 8.49 Mb
ePub File Size: 18.27 Mb
ISBN: 696-2-42073-697-3
Downloads: 1644
Price: Free* [*Free Regsitration Required]
Uploader: Kagam

Another hurdle for our public institutions is the availability of infusion pumps. Rev Esp Anestesiol Reanim. Traditionally, before the TCI system came about, intravenous anesthetics were administered using manual regimens. Individual effect-site concentrations of propofol at return of consciousness are related to the concentrations at loss of consciousness and age in neurosurgical patients.

Regardless of the instruments used or how accurate they may be, what is really important is knowing that we have the tools available and based on the estimated plasma levels, we can adjust the anesthesia to the different stages of the surgical procedure; in the case of remifentanyl, it can be adjusted to pfopofol specific conditions such as the age of the patient.

The proportional division of these lines allows the placement of different ages. TCI compared with manually controlled infusion of propofol: The influence of age on propofol pharmacodynamics.

For this, one pinpoints the red line located on the nomogram. If we were to infer from this model the drug concentrations needed for a target effect, and identified the different concentrations that cause the same effect, what would then be the ideal concentration of each drug for delivering adequate intraoperative anesthesia and a rapid recovery of the patient?


For the same case and at the moment of de-tubing the patient with the least incidence of cough possible, a CP between 3 and 3. Assessment of three parameter sets. Target controlled infusion in practice. Como citar este artigo. MeSH, NLM Introduction Total intravenous anesthesia, TIVA is a technique for administering general anesthesia exclusively intravenously; it uses a combination of drugs with the exception of the inhaled agents, including nitrous oxide 1.

The fast peripheral compartment V2 is the central compartment from which the drug perfuses rapidly.

Farmacocinética do propofol em nanoemulsão em cães

This equation is very simple as a basic model for the application of non-lineal regression used to estimate the pharmacokinetic parameters, to control the continuous intravenous drug infusion using a computer and do simulations or estimate dosing regimens How to cite this article.

Arterial farmaccocinetica samples were collected just before induction 02, 5, 10, 15, 30, and 60 minutes after the bolus dose, and after the end of the infusion at five, 10, 15, 30, 60, and 90 minutes and 2, 3, 4, 6, 10, and 24 hours.

Fentanyl and sufentanyl have an intermediate ke0 resulting in a slow onset of action 4 to 6 minutes. Pharmacokinetic model selection for target controlled infusions of propofol.

The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers. How will knowledge of the human genome affect drug therapy? Example 1 see figure 1.

In the present article the utilization of the nomograms are presented didactically via examples which permit the reader to assess her or his grade of comprehension and dispel doubts about the application of frmacocinetica pharmacokinetic concepts for remifentanil and propofol.


Interaction of propofol and sevoflurane on loss of consciousness and movement to skin incision during general anesthesia.

There was a problem providing the content you requested

Tracheal intubating conditions using propofol and remifentanil target-controlled infusions. Since Ve is a very small virtual volume, k1e and Ke1 do not represent any propogol values and thus are deleted.

Until now we have seen a lower drug consumption when the Schnider model is used These concentrations gave the fastest awakening — 6. Nomograms are a practical option for estimating the plasmatic CP concentration of a medicine and thus be able to administer it pharmacokinetically. Not farmacoconetica aware of the plasma concentrations during a procedure is like piloting an airplane just knowing how to start the engine, take-off and shutting down the engines for landing Relationship between the pharmacokinetics and pharmacodynamics prkpofol procainamide.

Manual versus target-controlled infusion remifentanil administration in spontaneously breathing patients. A similar trial by Breslin in showed similar results in terms of depth of anesthesia and awaking times. The most relevant articles were selected for this review and it was supplemented with anesthesia textbooks in the guearea of pharmacokinetics and total intravenous anesthesia.

Nomograms are tools that allow the administration of medicines pharmacokinetically.